Danish biotech firm Genmab saw its shares jump over 5% to $22.70 after announcing groundbreaking Phase 3 trial results for its lymphoma therapy. The EPCORE FL-1 study showed a 79% reduction in disease progression or death risk for patients with relapsed follicular lymphoma when treated with Epcoritamab combined with Rituximab and Lenalidomide. Both primary endpoints were met, with a remarkable 95.7% response rate. The U.S. FDA has granted accelerated review, with approval expected by November 30, potentially making this the first bispecific antibody combo for second-line treatment of the disease in the U.S.
Financial Momentum and Pipeline Strength
Genmab’s revenue grew 19% to $1.64 billion in H1 2025, driven by blockbuster drugs DARZALEX and Kesimpta. Operating profit nearly doubled to $548 million, prompting raised full-year guidance. Beyond Epcoritamab, the company is advancing Rinatabart sesutecan for endometrial cancer, bolstering its oncology portfolio. A strategic partnership with a major pharma firm enhances global commercialization prospects, positioning Genmab as a key player in innovative cancer therapies.